Objectives: To evaluate and correlate the immunoexpression of (TIBCs) Tumour Infiltrating B cells (CD20+) in Oral Squamous Cell Carcinoma with lymph node status. Material And Methods: The 30 paraffin blocks of histopathologically diagnosed cases of OSCC treated with neck dissection which was retrieved from the archives of the Department of Oral Pathology and Microbiology. The sample size of (n=15) cases showing lymph node metastasis pN(+) & (n=15) without lymph node involvement pN(–). We evaluated the expression of TIBCs using antibodies specific for B cell, in OSCC and correlated the same with lymph node status. Results: On statistically evaluating and correlating the mean immunoexpression of TIBCs (CD20+) with pathologic lymph node status in tumour front area of primary tumour, we found that the mean count of TIBCs (CD20+) in pN(+) cases was 21.92 whereas in pN(–) cases it was 22.51 ( p value : 0.902) by Mann Whitney Test. Conclusion: It is important to understand the diverse role of B cells & its immune response in cancer, yielding a novel role as a predictive & prognostic marker which impacts the therapeutic approaches.