Co–infections in H1N1 patients have higher complication rates. Our patient with H1N1 pneumonia presented with a unique combination of Aspergillus and CMV co–infections. Histopathological features of H1N1 were examined on the post–operative surgical specimen in our case, rather than on autopsy specimens as in the case of most studies in the literature. Features characterisitic of H1N1 virus were observed in the lobectomy specimen along with detection of fungal hyphae and incidental detection of cytomegaloviral inclusions. However, in the post–operative phase, the patient developed pneumatocoele and persistent air leak and finally succumbed. A high index of suspicion is necessary to identify such possible associations and prompt early appropriate management.