IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-4-18782 Original Research Paper A Retrospective Study on Distribution and Prevalence of Hyperuricemia Among Subjects in Ghaziabad (India) Nazir Dr. Iyman Rasool Dr. April 2019 8 4 01 02 ABSTRACT

Gout is a systemic disease that occurs due to the accumulation of monosodium urate crystals (MSU) in tissues. Uric acid is primarily synthesized in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid. The present study was designed to check the progress of hyperuricemia in different age and sex groups. A total of 150 patients with hyperuricemia were selected and the study was carried out at Santosh Hospital, Ghaziabad (India). This study included 90 females and 60 male patients with different age groups. Out of 150 study participants, 62 were hyperuricemia cases and the mean serum uric acid level was significantly higher in cases (6.40 ± 1.95) as compared to controls (5.30 ± 1.5). The overall prevalence of gout found was 41.33 % (62/150). Among 62 cases of hyperuricemia 36 were females (36/62= 58.06 %) versus 26 males (26/62 = 41.93 %). On the other hand the prevalence of male patients with hyperuricemia was 28.8 % (26/90) while as in females it was observed to be 40 % (36/90). During the study it was found that the prevalence of hyperuricemia was common in females than males. On the other hand maximum number of cases were reported in the age groups of 50–59 years (26/62 = 41.93 %) followed by 40–49 years (17/62 = 27.41 %), while as in other age groups the prevalence was 11.29 % (30–39 years) and 14.51 % in cases above 60 years of age. Least number of hyperuricemia cases were reported in age group below < 30 years with prevalence rate of 4.83 % respectively.