Background and Objective: Several patients with Type 2 Diabetes Mellitus (T2DM) are obese. Altered thyroid hormone status has been described in obese with Diabetes Mellitus (DM) patients. Methods: The study includes 100 obese with diabetes mellitus (DM) patients as a case and 100 healthy volunteers as a control. Thyroid profile was assayed in obese with DM patients. Results: In our study it was noted that thyroid dysfunction was prevalent in 42 patients out of 100 patients included of which 12 patients were hypothyroidism, 7 patients were hyperthyroidism, 22 patients were subclinical hypothyroidism and 1 patients were subclinical hyperthyroidism. Interpretation and Conclusion: The study advocates that screening should be recommended for all obese with DM patients to rule out thyroid dysfunction.