OBJECTIVE: The study aims to detect the aerobic bacteria isolated from cases of Ventilator–Associated Pneumonia (VAP) in the Intensive Care Unit(ICU) of a tertiary care Hospital, along with the outcome and mortality rate. MATERIALS AND METHOD: The study was conducted in the department of Microbiology in collaboration with the ICU on 130 patients admitted in the Medicine ICU with clinical suspicion of VAP. RESULT: Of the 130 patients, significant pathogens were recovered from 113. A total of 119 bacteria were isolated.The most predominant organism was Acinetobacter spp (37.8%).The mortality rate in patients of VAP was about 41.6%. CONCLUSION: Acinetobacter spp stood out as a significant pathogen with considerable virulence in nosocomial infection