Salvadora persica (Peelu ) miswak is a large, well–branched, and evergreen a tree resembling Salvadora oleoides found in the dry and arid region of India. Chewing sticks have been used for centuries for tooth cleaning and recommended by the World Health Organization. Salvadora persica is a promising product and is useful as analgesic, anticonvulsant, antibacterial, antimycotic, cytotoxic, diuretic, astringent and rheumatism. This review highlights the pharmacologic effects and therapeutic effects of Salvadora persica. The chemical constituents present in different parts of the plant are also discussed.