Background: The incidence of renal calculi has been increased in recent years. The treatment modalities in standard practise includes extracorporeal shock wave lithotripsy, percutaneous nephrolithotomy and laser stone fragmentation using ureteroscopy. Minimal invasive method Retrograde intrarenal surgery (RIRS) using ureteroscopy and laser lithotripsy has been shown to have better stone free rate with minimal complications. Whereas few other studies have reported upward migration of the stones and ureteral damage in RIRS. Hence the present study was conceived to assess the efficiency and complications of RIRS. Materials and Methods: We enrolled 25 participants in the mean age group of 42 years of either gender with renal calculi (unilateral or bilateral presentation) for our study and we monitored the patient preoperatively, intraoperatively and postoperatively following RIRS. We assessed their stone free status and complications following the surgery. Results: We observed 88% of stone free rate following RIRS with laser therapy. Conclusion: Retrograde intrarenal surgery with ureteroscopy along with laser therapy is effective and safe comparing other treatment modalities. Hence, we recommend ureteroscopy along with laser therapy for solitary and bilateral renal calculi.