Aims and objectives: Reporting a case of Hereditary Spherocytosis at AJIMS, Mangaluru. Materials and methods :Hereditary Spherocytosis is genetically determined hemolytic disorder with marked heterogenesity of clinical features ranging from asymptomatic condition to fulminant haemolytic anemia.The etiology of the disease is a deficiency in the membrane proteins resulting in the instability of the cytoskeleton. A 27 year old male presented with anemia, jaundice, splenomegaly with history of blood transfusions in the past. Results and conclusion: Blood film showed microspherocytes, reticulocytosis of 6% and negative direct antiglobulin test. Patient was managed conservatively with folic acid supplement and advised follow up for the need of splenectomy in near future as per severity of haemolysis.