Introduction :. Agitation is a state of uneasiness, anxiety, mental distress and irritability. It can arise from numerous sources including pain, physiological compromise or anxiety. Oral surgery, Ear, nose and throat surgeries are associated with a higher incidence of emergence agitation due to sense of suffocation. Infusion of dexmedetomidine an Alpha 2 adrenergic agonist ,diminishes agitation from general anaesthesia in pediatric patients. It also reduces anxiety and agitation while weaning a patient from ventilator in ICU. However, data regarding the outcome of dexmedetomidine on decreasing emergence agitation post general anaesthesia in adult subjects is limited. Perioperative use of dexmedetomidine diminishes postoperative opioid requirement, pain intensity and antiemetic therapy [1]. Material & Methods: This study entitled “Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after ENT, Oral and Maxillofacial surgeries.” was undertaken in Krishna Institute of Medical Sciences, Hospital and Research Centre, Karad, during the period December 2016 to July 2018. 130 patients, belonging to ASA physical status I or II, aged between 18 to 58 years, undergoing elective ENT and oral and maxillofacial surgeries were randomly selected. The study population was randomized by performing a random drawing and was divided into 2 groups with 65 patients in each group. • Study group D– received dexmedetomidine infusion at the rate of 0.4 mcg/kg/ hr from induction until extubation. (200 mcg dexmedetomidine was diluted in 50 ml normal saline and was made into a concentration of 4 mcg/ml in 50 ml) • Study group C– received equal volume of normal saline infusion. At the rate of 5–6 ml/hr. Result values were recorded using a preset proforma and following results were obtained. Results: The mean age of dexmedetomidine group was 36.44+ 9.26 years and saline was 37.95+9.22 years. There was no statistically significant difference in the age of patients between dexmedetomidine and saline groups with respect to age distribution. (P = 0.35) They were 46.15% males and 53.85 % females in dexmedetomidine group, 38.46% males and 61.54 % females in saline group. There was no statistically significant differentiation in gender in either groups. (P =0.35) The mean weight in dexmedetomidine group was 60.96±11.98 and saline group mean weight was 62.55± 10.7. It demonstrated no statistically significant differentiation in either of the groups (P = 0.42) The heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were indistinguishable in both groups. Group D demonstrated more stable haemodynamic changes during extubation when compared with group C (saline group) which was statistically significant At extubation heart rate – P value < 0.001, systolic blood pressure – P value <0.01 and mean arterial pressure P value< 0.01. No patient in both the groups had hypotension requiring ephedrine administration or bradycardia requiring atropine administration. The grades of cough assessed using cough scale during emergence showed no statistically significant differentiation in either groups (P value = 0.18) The recovery was assessed using Modified Aldrete score one hour after surgery and was similar in both groups with statistical insignificance. (P value = 0.15). The time required for extubation in both the groups was not statistically significant (P value = 0.41 ) There was increased incidence of agitation in the volume matched saline group (group C) with a statistically significant differentiation in both the groups (P value= 0.001). Conclusion : Dexmedetomidine a novel anaesthetic agent which is suitable for pre anaesthetic anxiolysis and sedation as well as intra and post operative analgesia. From our study, we have come to the conclusion that the maintenance of intraoperative dexmedetomidine infusion (0.4mcg/kg/hour) till extubation, produced smooth and haemodynamically stable parameters in the intraoperative period and at the time of extubation. Dexmedetomidine infusion also diminished the emergence agitation without any complications after ENT and OMFS surgeries in the immediate post–operative period