BACKGROUND: Surgical site infection (SSI) is a major cause of morbidity and mortality, increasing both the duration of patient hospitalization and hospital cost. AIMS AND OBJECTIVE : To identify the possible risk factors related to development of SSIs and the common pathogens encountered in development of SSIs and to Identifying the pathogens and their antimicrobial sensitivity provides help in empirical management of SSIs. METHODS AND MATERIALS: The present study at was done for a period of one year. During the study period a total of 916 surgeries were conducted and 82 defined cases of SSI as per CDC guidelines. RESULT: Overall prevalence of SSI in the present study was 8.9%. 33.81% were from the general surgery ward, 29.27% from orthopaedic unit and 35.46% from the obstetrics and gynaecology ward. Major prevalence of SSI was observed in cases of Hernia repair (8.92%) among the intestinal surgeries and least was noted among cases that underwent orthopaedic procedures (8.13%). Majority of the patients were in the age group range from 20–65 years. Of the 916 patients in the study group of one year, 62% were Males and 38% were females. 45% of cases underwent emergency surgery and 55% were elective procedures. The most commonly isolated pathogens in the study were staphylococcus aureus, Escherichia coli, and pseudomonas aeroginosa. CONCLUSION: Surgical site infections are a major problem in the surgical wards and its incidence is higher than that reported in developed countries. Multi–resistant staphylococcus aureus followed by Escherichia coli and Klebsiella pneumonia are common bacteria causing SSIs.