Background: Knowledge about the patterns of STIs in different geographical regions is necessary for evolving proper strategies for its control. If not managed properly they can promote HIV transmission. Aim: To study the pattern of STIs in patients attending Skin and VD clinic at MGM hospital, Aurangabad, Maharashtra. Materials and Methods:A Cross–sectional study was conducted between January 2017 to January 2018 to study the pattern of STI. Diseases were diagnosed on clinical basis and HIV,HBsAg,VDRL was done. Results: Out of 100 patients attending STI clinic,75 were males and 25 were females. STIs were high among married individuals. 48% of them showed genital molluscum, 32% showed genital herpes, 18% showed genital warts, least was chancroid and syphilis i.e. 1% each. Conclusion: Viral STIs were the most common among all STIs. The persistent recurrent nature of viral infections is responsible for their increase trend in the current STI scenario