IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-4-18977 Original Research Paper CLINICAL SPECTRUM AND OUTCOME OF PATIENTS WITH ACUTE VIRAL HEPATITIS A: A PROSPECTIVE STUDY. Naveed Anjum Qureshi Dr. April 2019 8 4 01 02 ABSTRACT

Background: Hepatitis is the Liver inflammation which can be described as either a clinical illness or histological findings associated with the disease. Hepatitis can be due to Viral, Drug Induced, Ischemic, Infections (such as Malaria, Enteric Fever), Alcoholic Hepatitis, Autoimmune, and Idiopathic. Acute phase may result in conditions ranging from subclinical disease, self limiting asymptomatic disease to acute fulminant hepatic failure. In this study we evaluate the epidemiology, clinical features and outcomes of Acute Viral Hepatitis due to Hepatitis A virus. Materials and methods: The study is designed to evaluate all cases presenting with the complaints of Fever, abdominal pain, nausea vomiting, anorexia, rash, altered sensorium, hepatosplenomegaly. Blood samples were taken at the time of presentation and sent to Microbiology Department and LFTs followed at an interval of 2 weeks. Results: A Total of 76 cases were recorded between June 1st 2018 to 28th February 2019 of which 50(65.8%) were males and rest were females(34.2%). 8 cases (10.38%) were reported after close contact with the confirmed cases while two deaths (2.5%) were noted in the pediatric age group due to acute fulminant hepatic failure in early course of the disease. Hepatis A virus infection was confirmed in 45 patients and variable rise in serum bilirubin ( range 1.5 to 32mg/dl) and liver enzymes (SGOT– 350 to 1700 and SGPT– 370 TO 1900) were noted. Conclusion: Acute viral hepatitis in epidemic form may occur due to feco–oral transmission of hepatitis A virus which may result in a subclinical infection to acute fulminant hepatitis. Patients usually present with nonspecific symptoms which can be attributed to any viral illness; however there is high elevation of liver enzymes in acute viral hepatitis due to hepatitis A infection