Severe deficiency of iodine leads to thyroid goitre, which is an abnormal diffused or nodular growth of the thyroid gland. Diagnosis of goitre warrants a thorough examination of history, physical and clinical examination, laboratory testing and ultrasonography (USG). Goitre encompasses a wide spectrum of thyroid function disorders from hyperthyroidism, euthyroidism to hypothyroidism. Therefore, the present study was conducted to understand the various varieties of thyroid disorders with goitre, their clinical behaviour and analyse the various diagnostic methods we embark on a clinical study of goitre. A prospective study, conducted in a hospital between October 2016 September 2018, included patients with goitre with >12 years of age. All the patient underwent clinical examination, thyroid function tests and USG of neck with colour doppler. Fifty (n=50, 7 males, 43 females, age range: 31–40 years) patients were included. Clinical examination detected 19 patients with hyperthyroidism, 20 with hypothyroidism and one with subclinical hypothyroidism. However, based on USG, 21 (42%) patients were hypothyroid, 21 (42%) were hyperthyroid and the rest 8 (16%) were euthyroid. As per clinical presentation, 34 (68%) were diffuse goitres,10 (20%) were solitary nodules and 6 (12%) were multinodular goitres. However, according to USG, diffuse hypertrophy, diffuse hypertrophy with multinodular goitre, diffuse hypertrophy with solitary thyroid, nodule multinodular goitre and solitary thyroid nodule were present in 25, 9, 1, 9 and 6 patients, respectively. The present study concludes that USG accurately diagnosed 66.66% of multinodular goitres which were missed clinically