Background: The interplay between thyroid and kidney functions has been known for several years. There is an increased prevalence of hypothyroidism in chronic kidney disease (CKD). Patients with (CKD) have an unacceptable high risk of premature death due to cardiovascular disease (CVD). This study was undertaken to correlate thyroid function and lipid profile in CKD patients. Materials and Methods: A cross sectional study was conducted among 50 chronic kidney disease patients at Rajendra Institute Of Medical Sciences Ranchi Jharkhand and compared with 50 age matched healthy controls. Demographic features (age and sex) and medical history of CKD of each were noted. 5ml of blood sample were analyzed for biochemical parameters i.e. .serum urea, creatinine, glucose, plasma proteins, lipid profile and thyroid hormones. Resuts: All the 50 CKD patients had thyroid dysfunction and dyslipidemia. Among these 52% had subclinical hypothyroidism and 48% had overt hypothyroidism. Patients in the overt to hypothyroidism group had significantly higher thyroid stimulating hormone (TSH), a lower free triiodothyronine (FT3) and lower free thyroxine (FT4) than those in control group. Hypercholesterolemia, hypertriglyceridemia, undesirable LDL cholesterol and low HDL cholesterol were observed in CKD patients which was statistically significant. Patients with hypothyroidism (clinical and subclinical) had significantly lower serum proteins and significantly higher serum urea, creatinine and plasma glucose. An increased prevalence of hypothyroidism was observed in CKD patients. Conclusion: On the basis of the data observed in the study, it can be suggested that CKD is associated with thyroid dysfunction, dyslipidemia and increased renal parameters. The study reveals the vulnerability of CKD patients with elevated lipid parameters towards CVD. By the outcomes of our study we can give insight to clinicians that the CKD should be screened for thyroid dysfunction to avoid the risk of CVD morbidity and mortality. As this study has some limitations like sample size, the study with large sample size is needed for establishing the tool to assess the CVD risk. The interplay between thyroid and kidney functions has been known for several years. There is an increased prevalence of hypothyroidism in chronic kidney disease (CKD). Patients with (CKD) have an unacceptable high risk of premature death due to cardiovascular disease (CVD). This study was undertaken to correlate thyroid function and lipid profile in CKD patients.