Introduction: Hysterectomy is the most common major gynecological procedure in the world for diagnosis of various diseases. Aim of this study was to study various uterine lesions in hysterectomy specimens and to correlate the findings with clinical indications. Material and Methods: Present study included 600 hysterectomy specimens done in the Dept of pathology at J.L.N. medical college Ajmer over the period of January 2017 to December 2017. : Results and Conclusions: The commonest benign lesion was leiomyoma (50%) followed by adenomyosis (34.5%), endometrial polyp (6.67%), cervical polyp (2.17%). In premalignant lesions 15 cases of endometrial hyperplasia and 5 cases of cervical dysplasia were observed. In malignant lesions endometrial carcinoma (1.5%, 9cases) was most common followed by cervical carcinoma (0.5%, 3cases), 1 case was leiomyosarcoma and low–grade endometrial stromal sarcoma each. The ultimate diagnosis and prognosis depends on the histopathological examination, therefore every operated specimen must be subjected to histopathology.