Haemoglobinopathies like thalassemia and sickle cell anemia has various complications. Splenomegaly is one of these complications that increases morbidity. Aim of this study was to study the role and outcome of the splenectomy surgery in patients of haemoglobinopathies with splenomegaly. Fifty admitted patients of haemoglobinopathy with splenomegaly were operated for splenectomy and the haematological parameters like haemoglobin level, haematocrit value, platelets count and frequency of blood transfusion were studied before and six months after the surgery along with surgical complications. It was found that haemoglobin level, haematocrit value, platelets count were raised and the frequency of blood transfusion was reduced after splenectomy surgery. Complications of surgery observed were wound infection in 3 (75%) and pneumonia in 1 (25%) patient