IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-4-19035 Original Research Paper A study on NT–pro BNP and Trop I as a marker of Cardiac Dysfunction In Cirrhotic Patients Of Jharkhand Keshav Dr. Aman Sinha Dr. April 2019 8 4 01 02 ABSTRACT

Cirrhosis is defined anatomically as a diffuse process with fibrosis and nodule formation and represents a terminal stage of a number of chronic liver diseases. Cirrhotic patients demonstrated both structural and functional cardiac abnormalities, resulting in both systolic and diastolic dysfunction, which appeared to correlate with the severity of the liver disease. In this study we plan to evaluate the clinical aspects of cirrhosis and its effect on cardiac structure and function as assessed by means of an echocardiogram. This hospital based observational study was carried on 150 cirrhotic patients admitted in Rajendra Institute of Medical Sciences, Ranchi, Jharkhand. The mean age of the study group was 42.30±8.42 SD with 127 (85%) males and 23 (15%) females. Maximum number of patients were alcoholic (44.66%) and Hepatitis B positive (34.66%) followed by unknown etiology/others (11.33%). Maximum number of patients 73(48.66%) in the study group belonged to child B as graded by Child Pugh Score followed by Child Pugh C (28%). There was statistically significant rise in NTProBNP and Troponin I levels as degree of liver dysfunction worsens. There was no significant correlation seen in NTProBNP and Troponin I in patients of cirrhosis of liver of different etiologies. NT–pro BNP and Trop I are important to detect early cardiac dysfunction and extent of cirrhotic cardiomyopathy generally correlates to the degree of liver insufficiency. Therefore, it is recommended that physicians should be aware for the possibility of myocardial diastolic dysfunction and can recommend measurement of the biomarkers for the same when suspected, in patients with chronic liver disease patients.