Hypertension is a disease that is chronic, progressive and requires treatment throughout life. The use of more than one drug causes hypertensive patients to be susceptible to drug interaction problems. Drug interactions are drug–related problems that can affect the outcome of patient therapy. This type of research is a retrospective descriptive study. Sampling was done by purposive sampling method with a total sample of 40 patients. The study used CRM (Customer Relationship Management) to facilitate data collection for hypertensive patients at Putri Hijau Hospital. The results showed that the characteristics of the most age range suffered from hypertension, namely the age of more than 65 years with the sex of 67.5% women and 32.5% men. The highest classification of hypertension was stage II hypertension by 70.0% with complications of dyspepsia by 10.0%. Drug interactions occur as much as 62.5% and are classified as moderate interactions with the pharmacokinetic mechanism