The mental health of university students is an area of increasing concern worldwide. Psychological distress encompasses symptoms of common mental health problems anxiety and depression. The transition from high school to higher education for students is a stressful experience as they struggle to cope with an array of changing conditions and students can face numerous stressors in addition to academic demands that can contribute to the development or exacerbation of mental health problems. This study determines the prevalence of psychological distress and associated factors among regular undergraduate students at Narayana Professional Colleges. Cross–sectional study conducted. The study used Self Reporting Questionnaire (SRQ–20) which was designed by WHO. Bivariate and Multiple logistic regressions have been used to determine associations. Higher level of psychological distress were observed among students who were not interested to join field of engineering, with less than mean adjustment score, with physical and mental illnesses. One–in–four students had psychological distress and this calls for some form of psychological and/ material support. Compromising students’ preference to get their field of interest had significant association with psychological distress