Introduction: Depression is a mental disorder of global concern, in India there is an increase incidence of depression due to drastically change in life style , urbanization and increase work pressure to perform best. Aim: Our study focused a change in biochemical parameters due to underline oxidative stress in patient of depression Material & method: Our hospital based case control study was done on 100 subject to find out a difference in levels of biochemical parameters in cases of depression as compared to control. Result: Cases of depression have found to have significant change in levels of biochemical parameters suggestive of an increase in oxidative stress as compared to control. Conclusion: Evaluation of important biomarkers could help in diagnosis of associated illness occur due to increase in level of oxidative stress in patient of depression