An immature tooth with pulpal necrosis and periapical pathology becomes a challenge to the endodontist. Such teeth can be treated with conventional apexification procedure with and without apical barriers. These case reports demonstrates use of an apical matrix barrier in form of a platelet rich fibrin membrane for the purpose of stabilization of MTA in root end apexification procedure together with use of diode laser for root canal sterilization in the form of Photoactivated Disinfection.