Oral squamous cell carcinoma is one of the leading cause of mortality and morbidity in developing countries. Its aggressiveness depends on various parameters of tumour itself and regional lymph node metastasis as well. This was a retrospective study conducted in Krishna Institute Of Medical Sciences, Karad over a period of two years with aim to study histomorphological prognostic factors and compare most used grading system in squamous cell carcinoma. There were total 133 specimens including biopsies and resection specimens. Comparison between Border’s classification and Anneroth’s grading system was done. We found that despite the widespread use of Broder’s classification, there is limited relationship with the grading and outcome of treatment and survival. Our study failed to observe any relationship between Broder’s system and patient’s prognosis. So multifactorial Anneroth’s grading system can be taken as a valuable diagnostic tool, in predicting lymph node metastasis and patient outcome