BACKGROUND– Despite many advances in the understanding of wound healing and scar formation, the treatment of keloid is still controversial. The aim of this study was to evaluate the efficacy and safety of intralesional triamcinolone, intralesional bleomycin and intralesional 5–fluorouracil in the treatment of keloid. METHODS– Total 90 patients were randomly divided into three groups (group A, B, C). Group A patients were given intralesional triamcinolone ( Regimen I ) 40mg/ml, group B patients were given intralesional 5–fluorouracil (Regimen II ) 50mg/ml and group C patients were given intralesional bleomycin (Regimen III ) 1 IU/ml. The efficacy of different treatment modalities were analyzed by evaluation of response to treatment, side effects and recurrence during follow up period. RESULTS– In regimen I, 20 (66.67%) patients showed excellent response and in regimen II, 13 (43.33%) patients showed excellent response.12 (40%) out of 30 patients showed recurrence in regimen I, followed by 5(16.67%) in regimen II, and 8 (26.67%) in regimen III, Local pain after injection was noted to be maximum in 7 patients followed by 6 patients and 5 patients in regimen III, II and I respectively . CONCLUSION– In terms of response to treatment, there was no significant difference found between response of regimen I Vs II and II Vs III. Regimen III was found less effective in comparison to regimen I which is statistically significant.