Primary Sjogren’s syndrome (pSS) is characterized by lymphocytic infiltration of exocrine glands leading to reduced saliva and tear production. Spectrum of renal involvement in pSS is broad like tubulointerstitial nephritis(TIN), renal tubular acidosis(RTA),Fanconi syndrome and glomerulonephritis. C linical presentation includes muscle weakness, cramps, periodic paralysis, bone pain due to electrolytes disturbances and metabolic acidosis. We describe here two cases of pSS presented as quadriparesis. Both cases had severe hypokalemia with normal anion gap acidosis due to distal renal tubular acidosis and positive antiSS–A and anti SS–B autoantibodies .Early diagnosis of pSS, prevents life threatining complications.