One of the most important and frequent changes that is encountered in the dengue is the hepato–splenomegaly. Not only the anatomical changes occur but the biochemical parameters that define the normal physiology are disturbed. The amount of the deviation differs depending on the severity of the infections. In sever dengue infection the hepatic enzymes are disturbed severely reflecting the severity of the infections. Whether this causes or is the reflectors of the mortality and morbidity has always been the question. So an attempt has been made to study the hepatic enzyme values and whether it reflects the prognosis is checked in this study.