Streptococcus pyogenes is one of the most common and ubiquitous human pathogens.. A total no of 215 children screened for beta haemolytic streptococci from throat swabs and all culture positives are grouped by enzymatic extraction method and all children were estimated for ASO titers. All results were analysed statistically. Out of 215 throat swabs 22.5% positive for beta haemolytic streptococci with highest percentage with group A(56.5%) and ASO titers estimated with 400IU/ml base line titers. The mean ASO titers obtained from test and control groups were 933 IU/ml and 686 IU/ml respectively. There is a statistical significance between case and controls p=< 0.05 there is a positive correlation (r =0.80) between high ASO titers and culture positives for BHS. The study established a high prevalence of BHS in the throat of children with predominant group A Streptococci leads to evident risk of RF and RHD