INTRODUCTION: Gender differences existed in treatment and outcome of patients with acute coronary syndrome(ACS). Women hospitalized with ACS are at a higher risk for adverse outcomes as compared to men. The aim of the study was to evaluate the clinical profile, and short–term outcome in women presenting with ACS, as a first manifestation of Ischemic Heart Disease. METHODS ; Data regarding demographic and clinical status was collected among 100 female patients of ACS at ICCU, PGIMS, Rohtak. Descriptive results are displayed as subgroups of STEMI, NSTEMI and UNSTABLE ANGINA(UA). All the categorical data are presented as frequency and percentages. All the numerical data are presented as mean±standard deviation. RESULTS ; 57 had STEMI, 9 patients had NSTEMI and 34 had UA. Mean age at admission was 60 + 11.34 years. Atypical presentations were noted in 34% women and one or more risk factors in 58%. Among 57 STEMI patients, anterior location of infarct predominated (68.42%). Mortality of 10% was observed in STEMI patients and overall 47 % females had one or more MACE. CONCLUSION ; This study conducted in women presenting with ACS, demonstrated peculiar features like old age, atypical presentation which resulted in higher incidence of associated risk factors in postmenopausal groups. Complications and mortality were comparable with previous studies. Non–adherence to treatment and lack of desire to have coronary intervention also explained the decreased short–term outcome in women.