Sacral plexus is the point of formation of many nerves which innervates the lower limb and perineum. They are found in the dorsal pelvic wall, ventral to the Piriformis, gives many branches including sciatic nerve. Among all the branches of sacral plexus, Sciatic Nerve variation is relatively common. During the routine cadaver dissection at PG department of Rachana Sharira, JSAM, Nadiad, a unilateral high division in the sciatic nerve was found in 61 year old female cadaver. The awareness of this anatomical variation is important as the nerve piercing the Piriformis muscle may compressed within the fibres of Piriformis which may cause unusual pain along the course of nerve. The knowledge of anatomical variations in the peripheral nerves is essential in the clinical as well as surgical set up.