Indian studies on zidovudine–induced myopathy are scarce. We documented the clinical muscular weakness, serum creatine phosphokinase (CK) levels and muscle histology in 47 patients with Human Immunodeficiency Virus infection men on prolonged zidovudine–based antiretroviral therapy (ART). Four patients had elevated CPK, none of them symptoms or objective muscle weakness. All muscle biopsies were normal on light microscopy. Zidovudine may be a well–tolerated drug as regards to myopathy in InVdian patients.