Surgery remains the mainstay of treatment for hydatid disease, with the risk of intra–operative spillage of scolices, giving rise to secondary hydatidosis. To minimize this scolicidal agents are injected to the cyst and the operative field is walled off with sponges soaked in scolicidal agents.1 However, this is associated with adverse effects like sclerosing cholangitis and fibrosing peritonitis.12–14 Chlorhexidine (0.05%) is one the commonly used scolicidal agent in hydatid disease with the least toxicity profile. We here report a case of metabolic acidosis with acute kidney injury following the use of Chlorhexidine as scolicidal. Summary: As there are no safe recommendation of upper limit of volume and concentration of Chlorhexidine as scolicidal, future research is needed.