Background: Expressed emotion refers to a global index of particular emotions, attitudes and behaviours expressed by relatives (caretaker) about a family member diagnosed with psychiatric illness. Materials and Methods: A total of 40 depressive patients were recruited from psychiatry OPD ,S.S.G.Hospital Vadodara and association between expressed emotions with demographic variables were measured. Results: Pearson correlation test was applied, in which p values was less than 0.05 for this study. Hence, association between severity of expressed emotion in caretakers for patients with duration of illness in patients with MDD significant . Conclusion: Expressed emotion of caretakers was associated with duration of illness in Major Depressive Disorder patients.