Priapism is defined as a persistent penile erection that continues hours (4 h) beyond, or is unrelated to, sexual stimulation. Priapism has incidence of 1.5 cases per 100 000 person–years. Haematological conditions are the cause of 20% of cases of priapism in men . Chronic myeloid leukemia (CML) accounts for half of this cases. Based on this case series we can conclude that as CML and various other hematological disorders can present as priapism , hence all the patients with priapism need to undergo basic hematological work up at diagnosis of priapism. Early diagnosis and prompt management of CML associated priapism can preserve male potency.