Odontogenic Keratocyst(OKC) is a developmental cyst which is well known for its aggressiveness and high incidence of recurrence. It possesses a unique challenge to the clinician in identifying and managing it. Importance was given for its invasiveness, recurrence and different treatment modalities but not for its potential to inherit in the family. This paper presents a series of 3 cases belonging to same family diagnosed with OKC and impact of familial history and genetic counselling on early diagnosis and treatment planning.