Maxillofacial region is affected by a various number of cysts when compared to any other part of the body. Radicular cysts are common odontogenic cyst of jaw bone which invariably presents as an oval, well defined radiolucency with radiopaque border around the apex of the involved tooth. They are leisurely growing, inflammatory cysts that arise from the epithelial residues in the periodontal ligament originating from pulpal necrosis of a non vital tooth. Owing to their otherwise asymptomatic nature these cysts sometimes present as large lesion accompanied by substantial amount of destruction of surrounding tissues. There are two recognised types of radicular cysts, those containing cavities completely enclosed in epithelial lining or true cysts, and those containing epithelium–lined cavities with open root canals. Radicular cysts are usually managed either by curettage and enucleation or by more conservative approach which is marsupialisation followed by enucleation. The purpose of this article is to report a case series of large radicular cysts and their management with review of literature