Introduction–Poisoning is the 4th common cause of mortality in India. About 50,000 deaths occur every year in India due to poisoning alone. According to National Crime Records Bureau, Ministry of Home Affairs Government of India In 2015, 37,232 people died of poisoning. Everyday almost 700 people die from poisonings in the world. Out of which 102 died in India daily in 2015.Objectives– 1.study of manifestation & outcome of different types of poisoning 2.The importance of toxidrome in early recognition of poisoning & its effect on outcome. Methods: This is a observational study, conducted in tertiary care teaching institutes of Western India. 200 poisoning patients were studied with their profile & outcome. Results: Incidence of poisoning was more common in the age group of 20–30yrs (41%) with predominant male gender (60%). Organophosphorus compound was most commonly used for poisoning with 31% death rate whereas Aluminium phosphide & Paraquat was associated with grave outcome. Conclusion– Poisoning incidence was more in young males. Stressful socioeconomic life style was the dominant contributing factor. Our study suggests early hospitalization with treatment of antidotes in rural area will reduce the morbidity and mortality.