Introduction: Chondromalacia patellae means “softening of the articular cartilage of the knee cap”. when the articular cartilage response to excessive and uneven pressure on the cartilage due to structural changes that leads to abnormal patella or runners patella.Mainly elderly and teenage group of people affected due to continuous erosion of cartilage covering patella. As a result pain and limitation in movement appears which ultimately Increases the risk of weakness in major muscles of thigh compartment. Aim: The study was aimed to find out the effectiveness of quadriceps isometric exercises in comparative to hamstring stretching exercises in condromalacia patella patients. Material and Methodology: The study was experimental in nature.Subjects were selected on a random basis from patients visiting the OPD having diagnosed with chondromalacia patella.. Total numbers of patients were selected divided into two groups and treatment were given one month . Results:–The result on the VAS scale were obtained before and after treatment between the isometric quadriceps exercises and hamstring stretching exercises showed a significant result.