PURPOSE OF STUDY:– The aim of this study was to compare operative factors, postoperative outcomes, and surgical complications of the head and neck dissection (ND) when using the harmonic scalpel (HS) versus Diathermy. OBJECTIVES:– 1.To assess the amount of blood loss, post operativepain relief and duration of the operation. 2. To assess the use of ultrasonic energy in comparison with diathermy. 3. To assess intra and postoperative complication. METHODS:– The material for the present study comprises of 60 cases admitted to Department of General Surgery in Padmashree Dr. D.Y.Patil hospital & research institute, Kolhapur from may 2015 to may 2017 a period of 24 months. The cases confirmed by the clinically palpable head and neck swelling or Mass and routine work were done and randomly selected for planned head and neck surgery using harmonic scalpel or Diathermy and observed for intraoperative blood loss, duration of operation, postoperative pain relief and complications. RESULTS:– The use of the HS reduced significantly the operating time, the intraoperative blood loss, the postoperative pain, and the volume of drainage. No significant difference was observed in mean hospital stay and postoperative complications. CONCLUSION: –The Harmonic Scalpel is a reliable and safe tool for reducing intraoperative blood loss, operative time, the volume of drainage and postoperative pain in patients undergoing head and neck dissection.