Aim of the Study: To compare efficacy of Esmolol and Fentanyl in attenuation of hemodynamic response during laryngoscopy and endotracheal intubation.

Materials and Methods:

50 adult patients were randomly allocated into two Groups, Group E received 0.2mg/kg body weight of iv Esmolol and Group F received 2µg/kg iv Fentanyl, 5 minutes before intubation.

 Results and Observations: Bolus dose of Esmolol 0.2 mg/kg and Fentanyl 2µg/kg administered 5 minutes before laryngoscopy and endotracheal intubation can effectively reduce the hemodynamic response associated with it. Esmolol and Fentanyl both can provide effective and reliable protection against such cardiovascular responses but cannot abolish it. Observed variance in heart rate, systolic pressure, diastolic pressure and mean arterial pressure during induction, intubation and 1,5,10 min post intubation are comparable across both the groups.

Conclusion: Esmolol and Fentanyl both can provide effective and definitive protection against hemodynamic response associated with laryngoscopy and endotracheal intubation when administered 5 minutes before laryngoscopy.