Background: In recent decades, the global emergence development of multidrug resistance and pan drug resistance in Pseudomonas aeruginosa has been observed. This opportunistic pathogen is responsible for causing various infections especially in the intensive care units, resulting almost 10% of hospital acquired infections. So, the aim of the study is to investigate the prevalence of infections due to CRPA among ICU admitted patients. Methods. Two hundred consecutive ICU patients in which Pseudomonas aeruginosa infection was isolated from different clinical specimens were enrolled in this retrospective multicenter case–control study from January 2018 to January 2019. The prevalence of carbapenemase resistance was analyzed by using Modified Kirby–Bauer disc diffusion technique for antimicrobial susceptibility testing. MBL production was detected by E–Test. Results. Out of 200 Pseudomonas aeruginosa isolates, a total of 62 isolates were screening test positive on the basis of their reduced susceptibility to meropenem or imipenem. 21/62 was confirmed MBL positive by E–Test. Conclusion: The rate of Carbapenem resistance was significantly higher in ICU with a stay for over a week. Increasing antimicrobial resistance and limited therapeutic options to treat carbapenem–resistant bacteria prompted us to evaluate the clinical outcomes associated with health related infections.