Background–In preemptive analgesia, the analgesic treatment is started before and is operational during the surgical procedure so that the physiological consequences of nociceptive transmission are reduced. Because of this protective effect on nociceptive pathways, preemptive analgesia decreases the incidence of hyperalgesia and allodynia after surgery.

Methods– This Hospital based, prospective, randomized, double blind, comparative study was conducted in Department of Anaesthesiology, Sawai Man Singh Medical College after obtaining approval from Institutional Ethics Committee and Research Review Board and written informed consent from all the patients.

Results– The mean duration of analgesic was 4.97 ± 2.98 hrs in group A  after which first rescue analgesic was required in group A, 6.49±2.98 hrs in group B  and  7.26±2.51 hrs in group C. The mean duration of analgesia after which second rescue analgesic was required was 9.77±1.95 hrs for group A, 13.36±5.21 hrs for group B and 13.13±4.15 hrs for group C. The mean duration of analgesia after which third rescue analgesic was required was 15.43±3.58 hrs for group A, 15.94±3.42 hrs for group B and 17.25±0.35 hrs for group C.

Conclusion– We conclude that pregabalin 75 mg is better drug for preemptive analgesia and it can be used safely as a part of multoimodal analgesia regimens