Ocular manifestations due to dengue fever are relatively rare but of great significance. The mechanisms responsible for the dengue eye disease are direct viral infection and the immunological phenomenon. A 23 year old male patient presented to the emergency department with the complaints of loss of vision in both the eyes. He gave history of fever 14 days prior. Diagnosis of bilateral panophthalmitis was made after detailed examination. Discussion: Development of bilateral panophthalmitis in a setting of dengue fever is a rare complication. Panophthalmitis in dengue could be a part of immunologic and inflammatory reaction. The onset of ocular findings coincide with the drop in the platelet count. Thrombophilia, from the time the fever had subsided and very high ESR demonstrates severe inflammation. Conclusion: Bilateral Panophthalmitis in a case of serology positive dengue fever – A Case report