The present study was undertaken to study the effect of vestibular stimulation on the lipid profile of women with premenstrual syndrome.PMS a common problem faced by the women in the reproductive age was found to affect the lipid profile. Studies have shown that total cholesterol and triglyceride level is increased and HDL level is decreased in women with PMS when compared to women without PMS. In this study a total of 30 women with PMS were selected using PMS questionnaire and was given vestibular stimulation for 2 months. Lipid profile was estimated before and after vestibular stimulation. The study showed that there is a significant decrease in the total serum cholesterol level. A decrease in the LDL and Triglyceride level and an increase in the HDL level were also found although it is insignificant.