A 49 year male presented with severe chest pain and vomiting followed by alcohol intake. Electrocardiogram showed ST elevation and T– wave inversion with echocardiogram showed low ejection fraction with wall motion abnormality typically apical wall akinetic and compensatory basal wall hyper contractibility. Coronary angiogram was normal. Upper GI endoscopy was showing hiatus hernia with erosive esophagitis and duodenitis. He recovered with proton pump inhibitor. This is a rare case of takotsubo cardiomyopathy (TCM) due to alcohol induced acute gastritis.