Background: Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self–worth, disturbed sleep or appetite, and poor concentration. Materials and Methods: A total of 40 depressive patients were recruited from psychiatric opd S.S.G.Hospital Vadodara, and then association between severity of depression with demographic variables were measured. Unpaired t test, ANOVA test and tukey pair wise comparisons were used to check association in this study. Results: This study found that severity of depression was not significantly associated with demographic variables in patient of Major Depressive Disorder. Conclusion: The comparison of the mean Hamilton Depression Rating Scale (HAMD)score in relation to age,sex,area occupation ,education and family type were carried out in which the p value obtained was statistically not significant (P>0.05), showing that the mean Hamilton Depression Rating Scale (HAMD)score is comparable between the various age groups.