Background: The cardiac manifestations in TA are the consequences of the various features related to TA; hypertension, pathologic involvements of the pulmonary/coronary artery, aortic regurgitation as well as direct involvement of the myocardium. Cardiac manifestations may represent another type of cardiovascular morbidity in TA patients. RESULTS: Among the 112 TA patients, 80 patients (71.42%) were female. The female to male ratio was 2.5: 1. Most of the patients experienced clinical signs or symptoms attributable to the disease at the age of less than 40 years. The mean age of the patients was 26.83± 9.94 years. Hypertension was the most common coexisting disease 72%. Diabetes mellitus, dyslipidemia were found in 4% and 36/112 (32.14%) patients, respectively. Those co–morbidities including hypertension, diabetes mellitus, and cerebrovascular events, etc. showed no statistical difference between the active and inactive TA groups. The common presenting symptoms were those that suggested vascular insufficiency; claudication (33%), fever (5%), lethargy (4%), arthralgia (3%) and carotidynia in some of the patients. 60 (53.57%) were classified as the active group at the time of the initial diagnosis. Out of the 80 females, 40 were in the active group and remaining 40 were having inactive disease. Incidence of bruit was slightly higher in patients with active disease than inactive disease. However, overall there was no statistical difference in the clinical symptoms and signs between the two groups. Most common symptom that suggested acute inflammation was fever and was found mainly in active takayasu arteritis group. The left subclavian artery was the most frequently involved branch followed by left common carotid artery, descending aorta and right common carotid artery. Generally, the most frequent feature of the involved vessels was stenosis except for the ascending thoracic aorta. The ascending thoracic aorta frequently appeared to have dilatation or aneurysmal change. Pulmonary artery involvement were observed in 3.57% patients. When these involved vessels were categorized by the International TA Conference in Tokyo 1994 classification,TYPE I (21.42%), TYPE IIA (14.28%), TYPE IIB (3.57%). TYPE III (10.71%), TYPE IV (3.57%), TYPE V (46.42%). TYPE V was the most common type followed by TYPE I, TYPE IIA and TYPE III. The active TA patients had more frequent involvement of the ascending aorta, aortic arch and its main branches (right innominate artery, both common carotid arteries, both subclavian arteries) than did the inactive group. Among 112 patients, 10.71% (12/112) patients underwent coronary angiography following symptoms suggestive of myocardial ischemia. CAG showed evidence of coronary artery disease with involvement of left anterior descending in the form of ostial lesion in 4 patients and 8 of them having double vessel disease. CONCLUSION: TYPE V was the most common type followed by TYPE I, TYPE IIA and TYPE III. The active Takayasu Arteritis patients had more frequent involvement of the ascending aorta, aortic arch and its main branches than did the inactive group. The left subclavian artery was the most frequently involved branch followed by left common carotid artery, descending aorta and right common carotid artery. Hypertension was the most common coexisting disease.