Loss of mandibular continuity results in deviation of remaining mandibular segment toward the resected side depending on the extent of osseous and soft tissue involvement, degree of tongue impaired, the loss of sensory and motor innervations, the type of wound closure, the presence of remaining natural teeth and finally the first initiation of prosthetic treatment. The earlier the mandibular guidance therapy is initiated in the course of treatment; the more successful is the patient’s definitive occlusal relationship. Prosthodontic treatment coupled with an exercise program helps in reducing mandibular deviation and improving masticatory efficiency. This case report describes prosthodontic management of a patient who has undergone a hemimandibulectomy 2 years back. The patient was rehabilitated using conventional mandibula & maxillary complete denture prosthesis designed to fulfill the patient’s needs and requirements.