AIMS & OBJECTIVES: The primary objective of this study was to assess percentage flow mediated dilatation (FMD) in patients with risk factors like smoking, diabetes, hypertension with or without stable ischaemic heart disease (SIHD) and compare it with the individuals without any risk factors. METHODS: Study was conducted on 100 patients. Percentage FMD was measured by the Angiodefender device and the results were compared. RESULTS: Percentage FMD of Stable ischaemic heart disease with other conventional risk factor was 6.65 ± 1.17 (p value < 0.001) whereas in patients without SIHD along with other conventional risk factor, percentage FMD was 8.77 ± 2.37 (p value < 0.001) as compared to normal population (11.81±1.03). CONCLUSION: Patient with risk factors like smoking, diabetes, hypertension with or without SIHD showed significantly decreased percentage FMD as compared to individuals without any risk factors.