BACK GROUND: Acute pancreatitis accounts for up to 5%of the patients presenting to the emergency department with abdominal pain. It is an inflammatory disease and it manifest with broad clinical spectrum varying from mild self limiting to severe form, such as pancreatic necrosis, multi organ failure and death. Early diagnosis and treatment of acute pancreatitis is critical in reducing the morbidity and mortality of the patients. Goal of this study is to throw light on urinary trypsinogen–2 as novel marker for diagnosis of acute pancreatitis.