Background: Essential Hypertension is a major health problem in developed as well as in developing countries. It is one of the most important public health challenges worldwide because of its high frequency and concomitant risks of cardiovascular and kidney disease. Hypertension and dyslipidemia are major risk factors for coronary artery disease (CAD) and account for >80% of death and disability in the low– and middle–income countries. Blood glucose levels in hypertensive cases were also included to find out the association of hyperglycemia with hypertension. Objective: The present study we try to study the role of lipid profile, and blood glucose in hypertension individuals. Materials and methods: The present study was carried out in the Department of Biochemistry on 100 subjects in the age group of 30–70 years, attended OP in Rama Medical College & Hospital, Kanpur. Among them 50 healthy subjects enrolled as control group remaining 50 Essential hypertension [EH] patients were served as case group. Lipid profile and RBS level were estimated by ERBA Auto analyzer. Results: The study showed that TG, Total cholesterol, LDL–C, VLDL–C and blood glucose levels were raised in patients with hypertension in comparison to controls. HDL–C levels were decreased in patients with hypertension in comparison to controls. There was negative correlation between cholesterol and HDL–C levels in cases where as a positive correlation was seen between cholesterol and LDL–C levels. Conclusions: Based on the obtained results the serum lipid profile and random blood glucose may be useful in identification of patients at risk of hypertension. Measuring TG, Total cholesterol, LDL–C, HDL, VLDL–C and blood glucose levels is a useful test as it carries important prognostic information.