Introduction: Appendectomy is one of the most commonly performed surgical procedure in the dept of general surgery . Appendectomy is performed by both open and laparoscopic methods. Still there is lack of consensus, which method is best. In this comparative study, we aimed to compare the laparoscopic and open technique in the treatment of acute appendicitis. Methods: Data collected from 100 consecutive patients with acute appendicitis were studied comparatively. These comprises 60 patients who underwent open appendectomy and 40 patients treated laparoscopically. The two groups were compared for operative time, length of hospital stay, postoperative pain, complication rate and return to normal activity. Results: Laparoscopic appendectomy was associated with a shorter hospital stay, less need for analgesia and with a faster return to normal activities. Operative time was significantly shorter in open group in comparison to laparoscopic procedure. Total number of complications were less in the laparoscopic group with a significantly lower incidence of surgical site infection. Conclusion: The laparoscopic approach is a safe and efficient operative procedure in appendectomy and it provides clinically beneficial advantages over open method ( including shorter hospital stay, decreased need for postoperative analgesia, early return to work, early food tolerance and lower rate of surgical site infection) against only marginally higher hospital costs and operative time.